Benjamin Tatman

Beyond Exchange: Making Solid-State Relaxation Dispersion Less Coherent

The measurement of Bloch-McConnell Relaxation Dispersion (BMRD) by NMR can provide useful insight into micro- and millisecond dynamics in biological systems. We recently demonstrated that the measurement of BMRD in the solid state has been plagued by three-spin recoupling conditions. The decoupling of these artefacts enables the measurement and quantification of BMRD down to previously inaccessible spin-lock frequencies, even in fully protonated samples. Spurred on by these measurements, we developed a new analytical framework for micro- to millisecond motional processes, beyond the assumption of n-site exchange common in such analyses.

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