Chemical Shift Imaging NMR for Probing Bacterial-Mammalian Crosstalk in the Human Large Intestine

Trey Koev – @TTKoev

Chemical shift imaging NMR allows us to exploit a naturally occurring gradient of commensal bacteria, mucosa and large intestinal colonocytes. Probing the metabolic crosstalk between bacteria and colonocytes in healthy and diseases (cancer) cell set-ups allows us to probe differences in the cell-cell communication on a molecular level, potentially enabling the development of novel treatment avenues for colorectal pathologies.