Determination of the predominant conformation of Arbidol solvates in scCO2 by NMR

Eventova Varvara – @evarvara24

Exploring the Conformers of Crystalline Solvates of Arbidol for Improved Healing Qualities in scCO2 by NMR#GlobalnmrTC2023 pic.twitter.com/zQ3FtA0pRe

— Eventova Varvara (@evarvara24) July 14, 2023

Crystalline forms of medicinal compounds in the form of crystalline solvates have increased solubility in water and can be used to improve therapeutic properties. When obtaining solvates, the choice of solvent is important. In this work, the predominant conformations of arbidol in scCO2+2% DMSO-d6 were determined by NMR and X-Ray methods. The results showed the promise of using scCO2 as an alternativevto organic solvents.