Protein Methyl-Side Chain Dynamics via Nanoparticle-Assisted NMR Spin Relaxation

Xinyao Xiang – @xxiang2022

I’m happy to share our story about methyl-NASR. It probe protein internal dynamics with the help of nanoparticles. #GlobalnmrTC2022 @global_nmr pic.twitter.com/jAvOj5NpAb

— xinyaoxiang (@xxiang2022) August 4, 2022

The nanoparticle-assisted NMR spin relaxation (NASR) method measures the enhancement in transverse spin relaxation in the presence of slowly tumbling nanoparticles. It uncovers protein internal motions on the previously unobservable nanosecond to microsecond regime. We recently extended our NASR method to methyl-side chains using 2H or 13C spin relaxation.