Amaria Javed
Dynamic nuclear polarization (DNP) boosts NMR sensitivity but suffers from electron-electron (e-e) interactions, reducing polarization transfer efficiency. We propose the Magic-NOVEL sequence to counteract these effects. Evaluating Lee-Goldburg NOVEL sequences, our theoretical and simulation results show enhanced electron-to-nucleus polarization transfer by weakening e-e interactions, improving DNP efficiency.
Julien Dieterich – @J_Dieterich_
Hyperpolarizing polymers (HYPOPs) are porous epoxy-amine polymers with covalently grafted nitroxide radicals. Their use in our HypFlow project aims to enable repeating multiple cycles of freeze-DNP-melt and liquid state analysis of a pure and undiluted sample. This work presents the first results of HYPOPs recorded in our 1 Tesla benchtop DNP polarizer operating at 77 Kelvin.
Raj Chaklashiya – @RajChaklashiya
Here we present design principles for Dynamic Nuclear Polarization (DNP) utilizing narrow-line Electron Spin Clusters (ESC) to achieve nuclear spin resonance matching (ESC-DNP) for 1H NMR signal enhancement at 7 T, with potential for wide radical design scope at high magnetic field and low microwave power.
Sajith V Sadasivan – @v_sadasivan
Optically activated DNP techniques involving triplet state excitation use non-equilibrium electron spin polarization for room temperature measurements. Despite the advancements in the field, electron spin dynamics during polarization transfer to nuclei remain unexplored. This study aims to understand the electron spin dynamics of a photoexcited triplet system coupled to nuclei.
Ribal Jabbour – @JabbourRibal
Traditional DNP transfer employs an indirect, spin-diffusion mediated process, transferring polarization from nuclei on the PA to solvent nuclei, and then to the target molecule nuclei. In contrast, direct transfer involves immediate polarization from the PA to the target molecule, bypassing any intermediary nuclei. We show the distinctions between indirect and direct transfer methods using AMUPol, a widely-used bis-nitroxide, at magnetic fields ranging from 9 T to 14 T. We demonstrate that with ASYMPol-POK (larger e-e couplings), superior direct transfer performance in deuterated DNP solvent is shown compared to AMUPol.
Natalie Ibbetson – @Natalieeibby
15N-DNP has been proven to work up to only 5 T, while other nuclei (13C, 31P) show enhancements up to 14.1 T. Here we show preliminary experiments conducted at 14.1 T on a solution of 15N-aniline doped with BDPA radical and numerical simulation of electron-nuclear hyperfine coupling.
Shubham Kumar Debadatta – @shubham_k_deb
The study explores enhancing NMR sensitivity using dynamic nuclear polarization with diamond NV-center, aiming to transfer polarization to nearby nuclear spin using NV-electron spin and microwave pulses, avoiding traditional cryogenic methods and costly equipment.
Tomasz Ratajczyk – @TRatajczykonX
Under specific conditions, orthohydrogen generated from parahydrogen can appear to have a partially negative 1H-NMR line (PNL). We present that in some solvents, PNL appears with a positive-negative pattern, while in others, PNL has a negative-positive pattern. The modulation of PNL in a mixture of various solvents will be discussed.
Madhu Basetti – @mbasetti
We are an imaging core group working in cancer research with preclinical imaging modalities for early detection and prognosis of cancer.
Michael Tayler – @NMRduino / @mcdtayler
NMRduino is a sub-MHz NMR spectrometer designed unsparingly for minimum complexity, providing low-entry-barrier-NMR for beginners and those who wish to build custom hardware. Utility ranges from exploration of basic NMR concepts such as phase cycling and coherence selection to advanced experimental control including low-frequency, low-field parahydrogen-induced hyperpolarization and spin decoupling.
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