The power of 19F-NMR: peptide-membrane binding is not that basic!

Tran Thanh Tam Pham – @tammyphamily

I design 19F-probe and apply #19FNMR techniques in bicelles to characterize #GPCR's ligand peptide interaction with membrane mimetics. So far, I identify the interaction region, carry #MolecularDynamics simulations and #WesternBlot to check for functionality. #GlobalnmrTC2023 pic.twitter.com/seGW0sDeGM

— Tam Pham (Tam the AuDHD Scientist) (@tammyphamily) July 20, 2023

My research focuses on a hormone, Apelin, important in forming new blood vessels and progressing chronic illnesses. It is not uncommon for peptides like Apelin to bind membrane before receptor-binding. Using 19F-Nuclear Magnetic Resonance, I characterize this binding suggesting a mechanism for Apelin that highlights membrane role in therapeutic delivery.