Tuesday, March 11, 2025 Magic-Angle Spinning Probes for High and Ultra-High Fields In this talk, I will describe recent progress in the development of custom-designed probes for magic-angle spinning solid-state NMR at 600, 750, 900 and 1100 MHz, including versions with improved sensitivity for 13C and 1H detection and applications to biological macromolecules including microcrystals, […]
Pulsed dynamic nuclear polarization All spectroscopic methods evolve from continuous-wave to pulsed. Magic-angle-spinning NMR in combination with dynamic nuclear polarization (MAS DNP) has, so far, been an exception. We try to change that by designing DNP pulse sequences. For the time being, pulsed DNP experiments are only possible at low magnetic fields. The basic reason […]
NMR Spectroscopy of Metal Halide Materials: Shining Opportunities& Challenging Nuclei Metal halide perovskites are a fascinating class of materials with far-reaching potential in various applications, including photovoltaics, photodetectors, light-emitting diodes, quantum sensing, X-ray detectors, and lasers. While this broad class of compounds continues to evolve, their atomic-level structure and dynamics is immensely complex due to […]
Parahydrogen-induced polarization at Low Magnetic Field Parahydrogen-induced polarization (PHIP) is a hyperpolarization method that can enhance NMR signals by several orders of magnitude. However, parahydrogen itself is NMR silent, so an important step in PHIP experiments is to convert the parahydrogen-derived singlet order into an observable magnetic state. In this educational seminar I will review […]
DNP NMR spectroscopy for biological applications Dynamic Nuclear Polarization (DNP) has revolutionized NMR spectroscopy, enabling powerful new approaches to investigate molecular structures and mechanisms in the life sciences. This tutorial offers a practical overview of biological DNP NMR spectroscopy. We begin by introducing the core components of modern DNP NMR, including instrumentation, hyperpolarization agents, sample […]
NUS Schedules Old and New, and How to Evaluate Them for Your Data Increased adoption of non-uniform sampling (NUS) for multi-dimensional NMR spans ever-broader classes of experiments and increasingly challenging applications, expanding the efficiency and scope of NMR. Given the landscape of established and emerging spectral analysis and reconstruction methods, there is increasing focus on […]
PyOR: A Versatile Magnetic Resonance Simulator for Learning and Teaching Python On Resonance (PyOR) is an open-source, object-oriented simulation package for exploring magnetic resonance phenomena in both liquid- and solid-state systems. Originally developed to model nonlinear NMR effects such as radiation damping and maser dynamics, PyOR has since evolved into a versatile and user-friendly framework. […]
Title to be announced Abstract to be announced. 8:00 AM California or 11:00 AM Boston or 5:00 PM Paris or 8:30 PM Delhi
Using 19F to Study Paramagnetic Biomolecules at the Nanoscale with Electron Nuclear Double Resonance 19F labels are well established in NMR spectroscopy and allow accessing specific molecular information within biomolecular frameworks such as proteins. In case of radical enzymes or paramagnetic metalloproteins, the molecular structure around the paramagnetic center within a radius of up to […]
Resolving Protein–Ligand Binding Pathways by NMR Relaxation: Conformational Selection vs Induced Fit Protein–ligand binding is essential for biological function. A long-standing question is whether ligand binding occurs via conformational selection (CS) or induced fit (IF). Using relaxation dispersion experiments with varying ligand concentration, we measured the 4-state binding kinetics encompassing both the CS and IF […]
