Altering a protein’s conformational space differentially regulates the host signalling pathway

Apurva phale – @ApurvaPhale

Viruses mimic host proteins to evade their immune response. A few baculoviruses do this by mimicking a widely present protein, ubiquitin. Interestingly, this viral protein can differentially regulate the forward and reverse pathways, not by changing the interaction interface but by modulating the protein’s conformational space as observed by eCPMG-NMR.