Does Duplex Impact Quadruplex: Characterization using NMR and MD Simulations

Rajesh Kumar Reddy Sannapureddi – @RR_Sannapureddi

How does duplex impact G4. Look at my poster for exciting work on Quadruplex-duplex.#GlobalnmrTC2022

Thanks @bwajtweeting for guidance and @iiserbhopal @serbonline for facilities and funding. pic.twitter.com/VSwP7ct5Iv

— Rajesh Sannapureddi (@RR_Sannapureddi) August 3, 2022

So far G-quadruplexes (G4) were studied individually, structural characteristics of G4s in presence of duplex is not well characterized. G4’s with duplex on 5’/3′ are designed to mimic genome. Here, we present atomistic characterization G4 and impact of 5’/3’ duplex and linker length using NMR and molecular dynamic (MD) simulations.