Mapping Molecular interactions of G quadruplex structure

Deepraj Negi – @ThevoiceDeepraj

Thrilled to present a poster titled "Mapping Molecular Interactions of G-Quadruplex Structure" at the #GlobalnmrTC2022. Thanks to @bwajtweeting for designing the project and @RR_Sannapureddi for scientific inputs. @chm_iiserb @iiserbhopal @hemakshizzaa #NMR pic.twitter.com/5yn9XNFW5k

— Deepraj_Negi (@ThevoiceDeepraj) August 3, 2022

G-quadruplexes (G4s) are known to be present in critical regions of the genome and their presence thus implicates them in several crucial biological processes. G4 is modulated by multiple factors, importantly by the primary nucleotides and the nature and concentration of the cation present. By altering the ions, loop length, and changing guanosine to inosine, the goal of this project is to determine the molecular interactions of the G-quad.