Probing the dynamics of YadA autotransporter in microcrystals and outer membranes hints at requirements for beta-barrel membrane insertion

Jayasubba Reddy Yarava – @JYarava

Most types of cells are protected and functionalized by a dense surface layer of glycans, proteoglycans, and glycolipids. This surface represents an under-explored space in structural biology that is almost impossible to recreate in vitro. Here, a realistic picture of YadA dynamics in asymmetric outer membrane environment was investigated using ssNMR and MD simulations.