Study of phosphorus clusters in tau fragment fibrils via multiple quantum solid-state NMR under DNP

Lokeswara Rao – @lokeswarnmr

Hyperphosphorylation of the protein tau is a characteristic of neurodegenerative diseases, yet its role is not entirely clear in promoting the tau aggregation propensity. Multiple quantum spin counting experiments were carried out to probe the phosphate species clustering and beta-sheet organization in the fibrils of phosphorylated tau fragments.