Uncovering global dynamics and an allosteric response in a synthetase cyclization domain

Kenneth Marincin – @KennyMarincin

Check out our group's latest research on the importance of protein dynamics in NRPS Cy domains. Happy to share this poster even in a virtual setting. A fantastic application of NMR methodologies. #GlobalnmrTC2022 pic.twitter.com/cFP2BUZOaF

— Kenny Marincin (@KennyMarincin) August 3, 2022

Nonribosomal peptide synthetase (NRPS) cyclization (Cy) domains are central to the biosynthesis of many medicinal and virulent compounds. Using solution NMR and mutagenesis, we showed that global dynamics convey an allosteric response to a partner domain which may be key to communication and substrate recognition in Cy domains.