Joao Medeiros Silva – @JMSism
The Envelope Protein of SARS-CoV-2 forms a viroporin that induces inflammation and acute respiratory symptoms associated with COVID-19. Using ssNMR, we describe the structure and gating mechanisms governing this viroporin. 19F-NMR experiments revealed an aromatic network regulating the channel, which adopts an open-configuration at acidic pH and presence of calcium.
Orr Simon Lusky – @ItIsLusk
We present a new solid state NMR method we developed for studying biological macromolecules called ‘Pulse induced resonance with angular dependent total enhancement’ (PIRATE). We demonstrate a new resonance condition, and the application on finding hydrogen bond patterns in intact viral RNA harvested directly from the MS2 bacteriophage.
Brad D. Price – @braddprice
An in-depth functional understanding of proteins requires a technique for tracking their movement in real time. We present high-field, (tr)EPR ‘filming’ of room-temperature protein motion as progress toward real-time distance tracking in lifelike environments.
Santiago Bussandri Mattia – @SantiBussandri
High-spin paramagnetic systems do not give rise to DNP effects by themselves, but in theory, this can be achieved by mixing these radicals with spin 1/2 radicals. In this work, we seek to demonstrate DNP using a mixture of spin 1/2 and higher spin radicals at high magnetic field.
Ravi Shankar Palani – @rshankarpalani
The Overhauser Effect DNP observed in insulating solids doped with BDPA radicals is investigated comprehensively for the role of individual 1H nuclear spins in hyperpolarizing the bulk, prompting us to selectively eliminate the 1H spins experiencing dominant DQ cross-relaxation, thereby obtaining improved bulk enhancements.
Asif Equbal – @asifequbal313
Dynamic nuclear polarization (DNP) is a technique for increasing the sensitivity of NMR by transferring the polarization from electron spins to nuclear spins. DNP has great potential, but experimental efficiencies are still far below the theoretical optimum, for reasons that are not well understood. In this poster, I will present some case studies showing how EPR can be used to measure electron spin dynamics and decipher the DNP mechanism.
Chuanyu Yan – @yan_chuanyu
The liquid-solid interface is of great importance in fundamental and applied research. However, the in-situ characterization of liquid-solid interfaces is very challenging. In this work, we demonstrated that {1H–29Si-}1H multiple-contact cross polarization with indirect detection (MCPi) solid-state nuclear magnetic resonance (ssNMR) spectroscopy is an excellent tool for studying dehydration and deuterium exchange at the solvent-silica interface.
Yady Senayda Garcia Castillo – @yadygarcia89
Composites between OIPCs and polymer particles have recently been of interest because they combine the non-flammability, non-volatility, plasticity, electrochemical, and thermal stability of OIPCs, while at the same offering the mechanical stability provided by the polymer. ssNMR is implemented to study the structural changes and ions dynamics and is correlated with Electrochemical Impedance Spectroscopy (EIS) to determine the ion transport in the composite. It is expected that the composite will take advantage of the intrinsic properties of the OIPC like plasticity, the mechanical strength of the polymer, and the formation of the interphase between them, which will add new properties.
Thomas Webber – @ThomasW35463255
Overhauser Dynamic Nuclear Polarization (ODNP) is a novel magnetic resonance tool which combines NMR and EPR to study local (within 1 nm) water dynamics near spin-labeled surfaces. I apply ODNP to study water diffusion in aqueous polymer systems, showing that polymer crowding slows molecular water significantly.
Riley W. Hooper – @rileyhooper97
Halogen NMR and NQR spectroscopy is often challenging due to large quadrupole moments for the NMR-active nuclei of Cl, Br, and I. Nevertheless, these nuclei can provide invaluable structural and dynamic information for materials. We have studied two such examples of lead-bromide materials via 79/81Br NMR and NQR spectroscopy.
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