Alexandre Poulhazan – @AlexPoulhazan
Velvet worms are fascinating animals that have a peculiar way to hunt. They eject a translucent liquid, the slime, that quickly forms sticky fibers trapping their preys. In addition to exciting recyclability of this natural glue, this slime has been characterized here by MAS-DNP and NMR, detecting unprecedented phosphonate-rich molecules.
Raj Chaklashiya – @RajChaklashiya
Multielectron Dynamic Nuclear Polarization (ME-DNP) is proposed to be a promising mechanism to achieve NMR signal enhancements due to its low microwave power requirement and scalability to high magnetic field. Here we explore experimentally and theoretically how to achieve this using a designed multielectron geometry of spatially proximal narrow-line radicals.
Mrudula Nikam – @mrudula_nikam
Proton is a preferred nucleus for detection, due to its higher gyromagnetic ratio. 1H-1H dipolar couplings are very strong due to the same reason. It causes broad peaks and reduced coherence lifetimes, even under very fast MAS frequencies (>60 kHz). A combination of fast MAS and pulsed homonuclear decoupling sequences can extend 1H coherence times to values higher than those possible with only one of these techniques. However, it is unclear if these two techniques can be combined to give an additive effect, especially at these fast MAS frequencies. I will discuss Phase Modulated Lee-Goldburg (PMLG) and TIlted Magic-Echo Sandwich with zero degree sandwich pulse (TIMES0) schemes for 1H-1H homonuclear decoupling which we have used to enhance the coherence lifetimes of protons in a uniformly labelled model peptide using both windowed and non-windowed schemes. We will suggest regimes in which these sequences can be applied to extend 1H coherence times by a factor of 2-3 over MAS alone, making the use of sequences such as INEPT feasible in non-deuterated proteins.
Yuhang Ren – @yuhangre
The nitrogen-vacancy (NV) center in diamond has enabled widespread study of nanoscale NMR. We present a 13C NV-detected NMR at 4.2 Tesla and show that the method can capture the intrinsic NMR spectrum. This work demonstrates a clear path to high resolution NV-detected NMR at high magnetic fields.
Baudouin DILLMANN – @dillmann_bd
The development of low field NMR has led to significant advancements in scientific research. Frugale, although not low-cost, offers sufficient performance for various applications. These scientific instruments play a crucial role in physics education, providing hands-on experience. Moreover, they are indispensable for scientific progress, facilitating breakthroughs across diverse disciplines.
Ruoru Ma – @ruoruma
In NMR, the baseline distortion usually appears as a curve displaced from the ideal flat line at Zero intensity. Corrections of these distortions is a necessary step in NMR spectra data processing to ensure the peak assignment as well as concentration prediction. The automatic baseline distortion correction method was reviewed.
Tran Thanh Tam Pham – @tammyphamily
My research focuses on a hormone, Apelin, important in forming new blood vessels and progressing chronic illnesses. It is not uncommon for peptides like Apelin to bind membrane before receptor-binding. Using 19F-Nuclear Magnetic Resonance, I characterize this binding suggesting a mechanism for Apelin that highlights membrane role in therapeutic delivery.
Alexander Barnes – @MagnetXander
I have a dream. I dream of hundreds and thousands of 100 Tesla Pulsed Dynamic Nuclear Polarization NMR spectrometers sitting on bench-tops and equipped with magic angle spinning spheres spinning a million times a second. To make this dream a reality, talented, ambitious, and dedicated scientists at the ETH Zurich are developing new magnets, microwave technology, and MAS instrumentation. Let me tell you about it.
Venkata SubbaRao Redrouthu – @rvsubbarao
The coherent transfer of electron spin polarization to nuclei by means of a microwave pulse sequence is a promising new approach to enhancing the sensitivity of solid-state nuclear magnetic resonance (NMR). The development of pulse sequences for dynamic nuclear polarization (DNP) of bulk nuclei is far from complete, as is the understanding of what makes a good DNP sequence. In this context, we introduce a new sequence, termed Two-Pulse Phase Modulation (TPPM) DNP. We provide a general theoretical description for electron–proton polarization transfer by periodic DNP pulse sequences and find it in excellent agreement with numerical simulations.
Zamir Shekh – @ProfZamirShekh
Nuclear magnetic resonance, or NMR, is a physical phenomenon that occurs when atomic nuclei are exposed to a specific frequency of electromagnetic radiation and a magnetic energy level resonance transition. One can obtain the NMR spectrum by identifying the absorption signals. It helps to investigate the architectures of molecules quantitatively based on the locations, intensities, and fine structure of resonance peaks. The size of the molecules of interest ranges from small chemical molecules to middle-sized biological molecules and even certain macromolecules like proteins and nucleic acids.
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