Isha Gautam
Understanding cell wall architecture and adaptation mechanism is essential for antifungal drug efficacies. The cell wall of Aspergillus fumigatus is characterized using solid-state NMR (ssNMR) divulged rigid core of chitin, β-1,3-glucan and α-1,3-glucan. Mobile domains contain galactoproteins and α-1,3-glucan. Hydrophobic and stiff cell walls were exploited in response to antifungals.
Madhu Basetti – @mbasetti
We are an imaging core group working in cancer research with preclinical imaging modalities for early detection and prognosis of cancer.
Annwesha Mazumdar – @Annwesha9
It’s a challenging task to detect the metabolites of designer drugs in the body. NMR spectroscopy is one of the validating techniques for its utility of metabolic fingerprinting of various designer drugs and has opened a new horizon in forensics. This paper highlights the recent developments of Nuclear Magnetic Resonance spectroscopy applied for the Forensic identification of various designer drugs.
Trey Koev – @TTKoev
Chemical shift imaging NMR allows us to exploit a naturally occurring gradient of commensal bacteria, mucosa and large intestinal colonocytes. Probing the metabolic crosstalk between bacteria and colonocytes in healthy and diseases (cancer) cell set-ups allows us to probe differences in the cell-cell communication on a molecular level, potentially enabling the development of novel treatment avenues for colorectal pathologies.
Alexandre Poulhazan – @AlexPoulhazan
Velvet worms are fascinating animals that have a peculiar way to hunt. They eject a translucent liquid, the slime, that quickly forms sticky fibers trapping their preys. In addition to exciting recyclability of this natural glue, this slime has been characterized here by MAS-DNP and NMR, detecting unprecedented phosphonate-rich molecules.
Tran Thanh Tam Pham – @tammyphamily
My research focuses on a hormone, Apelin, important in forming new blood vessels and progressing chronic illnesses. It is not uncommon for peptides like Apelin to bind membrane before receptor-binding. Using 19F-Nuclear Magnetic Resonance, I characterize this binding suggesting a mechanism for Apelin that highlights membrane role in therapeutic delivery.
Alexander Barnes – @MagnetXander
I have a dream. I dream of hundreds and thousands of 100 Tesla Pulsed Dynamic Nuclear Polarization NMR spectrometers sitting on bench-tops and equipped with magic angle spinning spheres spinning a million times a second. To make this dream a reality, talented, ambitious, and dedicated scientists at the ETH Zurich are developing new magnets, microwave technology, and MAS instrumentation. Let me tell you about it.
Julie Maibøll Buhl – @ll_buhl95024
The environment of biomolecular condensates, formed by LLPS, can be investigated using determined partitioning coefficients from a wide range of molecules. The time-zero 1H-13C HSQC was proposed and tested on a model system, where repetitions of the pulse sequence allows for correction of signal attenuation leading to precise quantification.
Valentina Sobornova – @VSobornova7121
https://twitter.com/VSobornova7121/status/1681239368332132353?s=20
The effect of mefenamic acid on the physicochemical and sorption properties of aerogel was studied. 1H and 13C MAS, T1-T2 RRCOSY and 1H-1H NOESY NMR experiments were carried out to study the conformational state of mefenamic acid and its effect on the aerogel structure. The results show that the group fraction of conformer groups of mefenamic acid changes by 53% in the presence of aerogel.
Plamen Chorbadzhiev – @NMR_P_Ch_0359
Craft beer have been gaining popularity for the past years, yet their chemical profile is poorly studied. 1H NMR metabolomics is used to determine their main components, as well as to distinguish four styles of beer – lager, pale ale, Indian pale ale and stout.
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