Konstantin Belov – @SCFsci
Determination of the predominant conformation of small molecules of drug in solution is one of the fundamental tasks of modern pharmaceutical and physical chemistry. Our research group “Fluid State NMR” has proposed a number of technical and methodological ways to solve this problem in the supercritical fluid environment.
Kelsey Marr – @kelsey_marr
Magnesium is the most abundant divalent cation in the cell and essential to nearly every biochemical reaction involving adenosine triphosphate and its lower energy counterpart, adenosine diphosphate. This work has focused on using 31P and 1H NMR as a tool to understand chemical and molecular interactions between ADP and Mg for evidence of nucleotide aggregation either by self-association or influenced by cations.
Covadonga Lucas-Torres – @covalucas
POPs deserve a particular attention among the chemical pollutants constituting the human exposome, since due to their lipophilic properties and resistance regarding the xenobiotic metabolism, they can bio-accumulate for long periods of time in adipose tissues. This innovative untargeted metabolomics study aims investigating the low-dose and chronic internal exposure to a cocktail of POPs, on multiple tissues known to accumulate these lipophilic compounds.
Jiaqi Lu – @Jiaqi_Lu22
Our research has unveiled the existence of hidden phosphate clusters, eluding spectroscopic detection. By manipulating solution conditions, notably pH, we expose their intricate behavior. Employing the power of chemical exchange saturation transfer, we discover new spectroscopic features, and provide further evidence for clustering. These results are important for studying phosphate function in the physiological environment.
Shadan Geshani – @ShGeshani
Vancomycin is a clinically-used glycopeptide antibiotic, used for the treatment of severe infections. Vancomycin kills bacteria by targeting cell wall precursors in the bacterial membrane, however, resistance mechanisms against this antibiotic have been widely known in pathogenic species. Molecular details of vancomycin’s action could only be studied in the absence of membranes. A better understanding of the molecular mechanism of vancomycin by ssNMR at atomic level will help to overcome this problem.
Sofia Mariasina and Kamil Aysin – @SMariasina and @Aysin_Kamil
We study new chromosomal rearrangements possibly causing lung cancer. We take human cell lines and reproduce in vitro mutations found in the tumors of cancer patients and test them for malignant transformation. Since cancer cells metabolism differs significantly from normal one we can use NMR metabolomics to detect malignancy
Mummidivarapu Varkrishna – @VarkrishnaM
The concept of photocatalytic water splitting is revolutionary however the applications aren’t so feasible to scale up. This research area has largely been dominated by the inorganic materials.However, organic ones are included every now and then. But the extent is less. The exploration and preparation of composites more based on the organic substances whereas the inorganic ones can be always supporting is a huge ocean of possibilities. And NMR is quite a powerful technique to explore it!
Deepraj Negi – @ThevoiceDeepraj
G-quadruplexes (G4s) are known to be present in critical regions of the genome and their presence thus implicates them in several crucial biological processes. G4 is modulated by multiple factors, importantly by the primary nucleotides and the nature and concentration of the cation present. By altering the ions, loop length, and changing guanosine to inosine, the goal of this project is to determine the molecular interactions of the G-quad.
Sophie Marianne Korn – @Sophie__Korn
How the SARS-CoV-2 nucleocapsid protein (N) recognizes specific RNA motifs remains unanswered. We use NMR to analyze the interactions of N’s N-terminal RNA-binding domain with RNA elements in the viral genomic RNA. The domain uses defined sensory residues to read intrinsic signatures of preferred RNA elements from available motifs.
Sofia Mariasina – @SMariasina
We try to assess vitamin status by 1H NMR using blood and urine samples of healthy volunteers who takes vitamins D, C, B1, B6, B9, or B12 as a supplementation to their diet. Some biomarkers of a person’s vitamin status were found, which can be used for personalized vitamin therapy.
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